An article published by Medscape reports that in a recent study by Dr. Joan Luby of Washington University School of Medicine in St. Louis, non-depressed preschool children whose parents showed more nurturing behaviors during a mildly stressful task were found to have hippocampal volume almost 10% greater than their peers whose parents showed fewer nurturing behaviors. The hippocampus affects cognitive functioning and emotion regulation.
Unfortunately, parental nurturing did not effect the hippocampal volume of children with early-onset depression.
Dr. Luby and colleagues think their findings could have “profound public health implications and suggest that greater public health emphasis on early parenting could be a very fruitful social investment.”
“The finding that early parenting support, a modifiable psychosocial factor, is directly related to healthy development of a key brain region known to impact cognitive functioning and emotion regulation opens an exciting opportunity to impact the development of children in a powerful and positive fashion”.
Multiple investigative groups at the 9th International Conference on Bipolar Disorder (ICBD) held in Pittsburgh in 2011 reported on the use of mobile phones or other automated processes to provide a more detailed ongoing record of a patient’s mood fluctuations and response to treatment. A particularly notable study by Nolen and colleagues described an electronic version of the life chart method (e-LCM) that would be accessible via internet, and which could be integrated with the patient’s file and used for research. These investigators developed software for a patient version and a clinician version. The web-based version is not yet available for patient use.
Editor’s Note: Until this and other useful electronic monitoring procedures become available, we recommend using the written version of a life chart to provide daily assessments of mood, side effects, and comorbid symptoms in order to provide a detailed numerical and graphic record with which to judge treatment response. This method is extremely valuable in developing new treatment approaches for those with treatment-resistant illness, and if patients keep these records, physicians will have optimal and detailed input in order to assess response and make treatment recommendations.
My Mood Monitor provides another available approach. This system was developed primarily as a screening instrument, but also includes a longitudinal monitoring component. It is not designed for daily monitoring, but can be used repeatedly with a minimal interval of one week between ratings.
We’ve written before about depressioncheck, My Mood Monitor’s iPhone app that can quickly screen for mood and anxiety disorders.
My Mood Monitor, a website for mental health screening, has introduced depressioncheck, a free, mobile version of their M-3 Checklist, a scientifically validated screening tool for mood and anxiety disorders that can now be used via Apple’s iPhone and iPod Touch. It can be found in the Itunes App Store.
Adapted from the online version, the mobile version provides a short series of questions that measure indicators of mental health. Developed by a team of mental health practitioners and experts, the checklist takes only three minutes to complete. It is ideal to fill out in the waiting room prior to an appointment with a general practitioner so the doctor can be made aware of potential problems in the area of mental health. Depressioncheck is appropriate for those 18 years and older and its accuracy was confirmed in an article published in the Annals of Family Medicine in March 2010.
We recommend My Mood Monitor and the new mobile application as simple and reliable screening tools that can assess the presence of unipolar and bipolar mood and anxiety disorders, including obsessive-compulsive disorder, panic disorder, and PTSD. Read more
If you have unipolar depression or bipolar disorder and are having trouble stabilizing your mood, we recommend nightly charting of mood, medications and side effects on the easy-to-use Monthly Mood Chart Personal Calendar (pictured below) or the National Institute of Mental Health Life Chart (NIMH-LCM), both of which are available for download.
Click on the Life Charts tab above to download the personal calendar, which includes space for rating mood, functioning, hours of sleep, life events, side effects, and other symptoms such as anxiety. Then bring the chart to each visit with your physician to help in the assessment of treatments.
Life charting can help determine which medications are working partially and need to be augmented further, and which need to be eliminated because of side effects. Since there are now many potential treatments for depression and bipolar disorder (some FDA-approved and some not), a careful assessment of how well each new treatment works for a particular patient is essential to finding the optimal treatment regimen.
EDITOR’S NOTE: Dr. Gagin Joshi of Massachusetts General Hospital, who presented the work on carbamazepine and lamotrigine on page 1 provided us with his own general treatment algorithm for youngsters with bipolar disorder.
Joshi typically starts with 0.5 to 2 gms of omega-3 fatty acids because of their benign side-effects profile, the many studies suggesting they are effective in adult mood disorders, and a recent article indicating that they were effective in preventing the conversion of prodromal schizophrenia into full-blown illness in a randomized double-blind controlled study in Australia.
After the omega-3 fatty acids, Joshi’s second choice is typically the atypical antipsychotic aripiprazole (Abilify) because of its lesser degree of weight gain compared to atypicals quetiapine (Seroquel) or risperidone (Risperidol). Risperidone can be a third option if aripiprazole is not effective or tolerated.
We’ve just posted a more attractive and user-friendly mood chart you can use to keep track of your illness, how you respond to your medications, and any side effects you may experience. See Life Charting for Patients, or download the chart here:
You can print extras of pages 5 and 6 for each following month.