Botox May Improve Depression

March 4, 2013 · Posted in Potential Treatments 

botox injectionRelaxing facial frown muscles with Botox may produce antidepressant effects. The muscles on the forehead between the eyebrows tend to tense and constrict during episodes of depression, anxiety, and grief. A placebo-controlled clinical trial by Eric Finzi and Norm Rosenthal has shown that paralyzing these frown muscles can produce antidepressant results.

Study participants with treatment-resistant depression received either paralyzing injections of botulinum toxin, better know by its trade name Botox, or placebo injections. The antidepressant response rate was 51% among patients who received Botox and 14% among those who received placebo. The remission rate was 27.3% with Botox versus 7.3% with placebo injections. These data are particularly striking because these patients had, on average, been ill for more than two years, during which time they had been through multiple unsuccessful antidepressant trials.

In 1872, Charles Darwin emphasized the importance of facial muscles in social communication and affect, and in 1890 William James suggested that sensory feedback from musculature changed people’s affect, rather than the opposite and conventional view that affective and emotional states cause muscles to tense and contract. The new data from Finzi and Rosenthal’s study are consistent with James’ view.

The investigators concluded that the data from this study suggest frowning itself may cause depression. More controlled trials using other injection sites would be helpful to further document the efficacy and selectivity of these Botox injections for the treatment of depression.


Comments are closed. If you enjoyed this article, please consider sharing it! Related articles uterine fibroids introduction uterine fibroid (also uterine leiomyoma, myoma, fibromyoma, leiofibromyoma, fibroleiomyoma, and fibroma) (plural of myoma... 200452(4):704acirceuroldquo708. Com video: chemo booster cuts treatment time by two months symptoms: learn what to look for and what the symptoms mean prognosis: early detection and new treatments improve survival rates highlights diagnosis resources introduction treatment references risk factors medications resources complications surgical alternatives to hysterectomy references symptoms hysterectomy highlights uterine fibroids uterine fibroids, also called leimyomas or myomas, are non-cancerous growths that originate in the thick wall of the uterus. D. Any procedure for myomectomy is very complex. Medications birth control pills levonorgestrel iud gnrh analogs such as , which can shrink the fibroids before surgery aromatase inhibitors such as anastrozole and letrozole have been used under experimental conditions. user reviews viagra daily use The embolic particles most commonly used in ufe have been available with fda approval for use in people for more than 20 years. viagra ve viagra karş Any procedure for myomectomy is very complex. Natural remedies require some dedication and patience. order real viagra online De rooy (westeinde hospital, the hague, the netherlands) m. Pain that could last for months. viagra women price Saharareporters has carefully followed her case since she was airlifted from abuja to germany one month ago when we were first told that she had suffered food poisoning.