Inflammation Plays a Role in Fear Memories

June 24, 2016 · Posted in Neurobiology 

inflammation in fear memories

People with post-traumatic stress disorder (PTSD) often experience fearful memories of the trauma they witnessed. Researchers are working to determine the neurobiological basis for these persistent fear memories in order to better treat PTSD. Current treatments mainly target the central nervous system. Because many people with PTSD have elevated levels of pro-inflammatory immune molecules in their blood, there has been a recent push to determine whether targeting that inflammation may be another way of treating PTSD.

A recent study by researchers Matthew Young and Leonard Howell used an animal model to learn more about the link between trauma, inflammation, and fear memories. The researchers exposed mice to a trauma that produced both a persistent fear response and an increase in inflammatory molecules in the blood. Some of the mice were also given antibodies to neutralize the inflammatory immune response. When the mice were exposed to a cue meant to remind them of the trauma, levels of the inflammatory molecule IL-6 spiked again. When the mice were given antibodies to neutralize IL-6 just before being exposed to the cue, they produced less of a fear reaction.

The researchers, who presented their work at a scientific meeting in December, concluded that traumatic experiences produce not only persistent fearful memories, but also an immune reaction. They believe that the spike in IL-6 following trauma plays a role in the persistence of those memories, and that elevated IL-6 in the blood may explain symptoms of PTSD and other disorders that involve fear learning (such as phobias).

Comments

Comments are closed.

One treatment is called uterine fibroid embolization. ntl-pro.com/xaw-158139/ I also have several friends with the same condition - none of us knew anything about fibroids or their symptoms unitl i was referred to dr lamaro. They finally started getting results naturally after years of struggling to get rid of their uterine fibroids using conventional methods! Warning: common drugs used to treat uterine fibroids can have serious side effects, damage your digestive system and may block your chances of havingchildren common drugs that are prescribed to treat fibroids such as: oral contraceptives, nonsteroidal anti-inflammatory drugs (nsaids) and androgens fail to tackle the root cause of fibroids ad most often can cause the following side effects: leg swellings cardiovascular problems and heart attacks digestive system disorders myriad of pcos symptoms such as: acne, facial hair, deep voice and depression excessive weight gain damage to your reproductive system (it can seriously hinder your chances of getting pregnant) fact: uterine fibroids surgery is not always necessary and can lead to serious consequences and irreversible infertility surgery should be considered when there is a clear danger from uterine fibroids (having cancerous fibroids is just one example). viagra buy bangkok 02. National institute of child health human development. http://joshlinkfoundation.org/puj-156447/ abefoto.com/qby-158362/ They finally started getting results naturally after years of struggling to get rid of their uterine fibroids using conventional methods! Warning: common drugs used to treat uterine fibroids can have serious side effects, damage your digestive system and may block your chances of havingchildren common drugs that are prescribed to treat fibroids such as: oral contraceptives, nonsteroidal anti-inflammatory drugs (nsaids) and androgens fail to tackle the root cause of fibroids ad most often can cause the following side effects: leg swellings cardiovascular problems and heart attacks digestive system disorders myriad of pcos symptoms such as: acne, facial hair, deep voice and depression excessive weight gain damage to your reproductive system (it can seriously hinder your chances of getting pregnant) fact: uterine fibroids surgery is not always necessary and can lead to serious consequences and irreversible infertility surgery should be considered when there is a clear danger from uterine fibroids (having cancerous fibroids is just one example). Uterine fibroids can grow in a way that: distorts the uterus fibroids that develop outside the uterus can alter the shape of the uterine cavity, or compress the fallopian tubes preventing conception. What is the success rate of ufe? According to the combined results of major studies of ufe, the average success rate is approximately 90 percent. viagra dosage wikipedia jlcom.ca/ojg-158582/ National institute of child health human development. The investigators found no significant differences between the groups in the rates of overall symptom improvement and patient satisfaction with outcome, but the rate of subsequent interventions was higher for the uae than for the myomectomy group (p = 0. carpinteriatoribio.es/wlc-158547/ Follow-up studies showed variable results with volume reduction of fibroids ranging from 31% to about 80% . franklinspecialneedscommunitysupport.com/mannersideas/reissues.php?bhg=158667 http://stevenschram.com/ddv-158751/ quot sign up for women's health to get tips for staying healthy and fit. http://freedomsfury.net/jbc-156052/ What is the success rate of ufe? According to the combined results of major studies of ufe, the average success rate is approximately 90 percent. This site uses cookies.