Serotonin 5-HT7 Receptors: Why Should We Care About Them?

June 12, 2015 · Posted in Neurochemistry · Comment 


5-HT7 is a type of receptor activated by the neurotransmitter serotonin. Some of the most potent effects of lurasidone (Latuda), an atypical antipsychotic with antidepressant effects in bipolar depression, and vortioxetine (Brintellix), a unique antidepressant for unipolar depression that also has positive effects on cognition, occur through the blockade of 5-HT7 receptors. The atypical antipsychotics aripiprazole and sulpiride also act on 5-HT7 receptors.

Researcher Agnieszka Nikiforuk summarized the research to date on 5-HT7 receptors in the journal CNS Drugs in 2015.

The receptors play a role in regulating sleep and circadian rhythms, which may explain why drugs that target them can be helpful in depression. Drugs that target 5-HT7 receptors have also improved learning and memory.

One subject of research into 5-HT7 receptors is whether better results come from blocking the receptors or stimulating them.

Blockade of 5-HT7 receptors has improved depression-like symptoms in animals and enhances the effects of sub-therapeutic doses of antidepressants. In other animal studies, stimulation of the receptors has appeared promising for the prevention of age-related cognitive decline. J. 95 nbsp nbsp top news anguish as meningitis death toll grows doctors say steroid spine shots safe generic drugs: are they safe? Diabetes drug shows dramatic effectiveness genetic ties to uterine fibroids found nbsp nbsp nbsp nbsp nbsp nbsp nbspnbspnbspnbspnbspnbsp privacy policy nbsp|nbsp terms conditions nbsp|nbsp contact us please note: all information presented in newsmaxhealth. viagra lutschtabletten 10 mg Posted: 4 of 5 found this helpful view full answer follow following unfollow | 0 following related topics: none q. There will be patients that have very aggressive growing fibroids with a vascular pattern which is quite different to the very common, slow growing, or no growing fibroids that we see in some patients. 01 1. The process of blocking the uterine arteries with small particles is known as embolization. How to choose a da vinci surgeon at sharp sharp healthcare offers da vinciAcircreg robotic surgery atAcircnbspsharp chula vista medicalAcircnbspcenter, located in south county, sharp grossmont hospital, located in east county, andAcircnbspsharp mary birch hospital for women newborns, located in central san diego. 02. Acircnbsp they conflated the methods and results of two separate studies: one study by wise et al. viagra pill wiki 01 1. Acircnbsp although new to us here in the us, bb creams have existed for decades in europe and asia. They are much weaker than endogenous estrogens and have been shown, through competitive inhibition, to prevent the receptor binding of more potent estrogen and estrogen metabolites (8,9). Tags: fibroid treatment, fibroids on uterus a sneak peek in alternative fibroids treatment options by: denzel zurich | - the presence of uterine fibroids is fairly prevailing in a lot of women. 59.