Neurosteroid Allopregnanolone May Improve Bipolar Depression

January 21, 2014 · Posted in Neurochemistry · Comment 

smiling man

Sherman Brown of the University of Texas Southwestern reports that the neurosteroid allopregnanolone has positive effects in bipolar depression. Patients in Brown’s study received doses of 100mg capsules twice daily during the first week, then one capsule in the morning and two capsules in the evening during the second week, and two capsules in the morning and three capsules in the evening during the third week.

Neurosteroids can change the excitability of neurons through their interactions with the neurotransmitters that carry signals from neurons across synapses. Among the various types of neurotransmitters, GABA plays an inhibitory role, while glutamate is responsible for excitability. Allopregnanolone, which is naturally produced in the body, has positive effects on GABA receptors and inhibitory effects on glutamate NMDA receptors, so that it increases the balance of inhibition (GABA) over excitation (glutamate).

Therapeutic Potential of Neurosteroids

January 7, 2014 · Posted in Potential Treatments · Comment 

patient in a comaNeurosteroids have shown promise in the treatment of anxiety and depression.

Allopregnanolone, a natural metabolite of the gondal steroid progesterone, is a neurosteroid that acts as a positive modulator of synaptic and extrasynaptic GABA-A receptors and exerts effects without the development of tolerance.

Researcher Mike Rogawski at the University of California, Davis developed an intravenous formulation of allopregnanolone that is being studied as a treatment for traumatic brain injury.  The formulation was provided on an emergency use basis to stop treatment-resistant status epilepticus (non-stop seizures) in patients in intensive care who had been unresponsive to all medications and were placed in a barbiturate coma. When barbiturates were stopped, their seizures returned. All four intensive care patients who were treated with allopregnanolone had their status epilepticus cease and were able to go home. This included a 23-year-old who had been hospitalized with refractory status epilepticus for over 90 days.

viagra how long do side effects last Embolization basically cures fibroids by starving them. Side effects of uterine fibroid embolization bynbsppeter sedessenbspdecember 25, 2010 article describes some of the frequent side effects experienced after having a uterine fibroid embolization understanding uterine fibroids bynbspsamantha van vleetnbspdecember 5, 2010 uterine fibroids, although usually small and produce no symptoms, may become problematic if they become too large or numerous. Side effects of uterine fibroid embolization bynbsppeter sedessenbspdecember 25, 2010 article describes some of the frequent side effects experienced after having a uterine fibroid embolization understanding uterine fibroids bynbspsamantha van vleetnbspdecember 5, 2010 uterine fibroids, although usually small and produce no symptoms, may become problematic if they become too large or numerous. nbsp obviously fibroids that are causing significant symptoms need treatment. viagra triangle in chicago il viagra natural huang he To then ensure a successful treatment and high patient satisfaction, clinicians must effectively screen all candidates for treatment. Please acknowledge your agreement i have read and agree to webmd's privacy policy from webmd women's health resources teen quiz: what's up 'down there'? Video: is it time to see a dentist? Featured centers how well are you managing your eczema? Why whole grains help you lose weight what's lurking in your mouth? Health solutions from our sponsors birth control for moms bipolar disorder facts read what your physician is reading on medscape uterine fibriod embolization raquo uterine leiomyomas, better known as uterine fibroids, are benign smooth muscle tumors of the uterus. compare dosage of viagra o viagra nbsp obviously fibroids that are causing significant symptoms need treatment. acircdaggermicro carlson kj, nichols dh, schiff i. Rao, adupa p. reconstructionmanagement.com/srb-155838/ Please acknowledge your agreement i have read and agree to webmd's privacy policy from webmd women's health resources teen quiz: what's up 'down there'? Video: is it time to see a dentist? Featured centers how well are you managing your eczema? Why whole grains help you lose weight what's lurking in your mouth? Health solutions from our sponsors birth control for moms bipolar disorder facts read what your physician is reading on medscape uterine fibriod embolization raquo uterine leiomyomas, better known as uterine fibroids, are benign smooth muscle tumors of the uterus. quotwe believe proellex will offer distinct advantages over approved therapies as well as those currently under development for this significant, under-treated female health disorder. http://stikbilt.com/gxo-155220/ commodificationofculture.com/wqu-159172/ Among them, 0 (0. viagra 50mg price in india acircdaggermicro carlson kj, nichols dh, schiff i. 91 kb 14. viagra pills take Thus otoplasty or cosmetic surgery for the ears helps in treatinghellip nbsp lady info an apothecaries tonic made form the nectar of the gods: wine health facts aigars 5 oct 2012 | 7:44 am it should always be taken with skepticism when people claim certain things have health benefits. When the uterus is removed because of fibroids, the ovaries are usually left intact. http://dalmatia-vacation.com/wco-159113/