Dextromethorphan potentiates the anti-depressant effects of SSRIs

Maji et al reported in Psychiatry Research (2024) that dextromethorphan 30mg compared to placebo potentiated the antidepressant effects of SSRIs on all measures and had few side effects.  It is FDA-approved to potentiate bupropion.  

Now it looks like a more general property.

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