NAD+ Supplements May Not Contain Much NAD+

August 8, 2017 · Posted in Potential Treatments · Comment 
vitamin B3

Vitamin B3 supplements might be a more effective alternative to NAD+ supplements.

NAD, or nicotinamide adenine dinucleotide, is found in all living cells. Its oxidized form, NAD+, has become popular as a nutritional supplement following a 2013 Harvard study that suggested it might slow aging in mice. However, commercially available NAD+ supplements may contain less than 100mg of NAD+, when ten times that amount would be required to produce any effect. NAD+ has not been tested in clinical trials.

Vitamin B3 is a better-tested alternative. A 2016 controlled clinical trial of a type of vitamin B3 called nicotinamide riboside (NR) found that this supplement was safe for humans and increased levels of NAD+. In the study by Samuel A.J. Trammell and colleagues in the journal Nature Communications, single doses of 100mg, 300mg, and 1000mg were all found to be safe. Larger doses increased NAD+ metabolism by greater amounts.

Check with your doctor before taking an NAD+ or vitamin B supplements.

Coenzyme NAD+ Postpones Aging in Mice and Worms

August 7, 2017 · Posted in Potential Treatments · Comment 

mouseAging cells seem to lose their ability to repair DNA, while the mitochondria that power cells also become less reliable. A coenzyme called NAD+ may be able to postpone these changes. NAD+, which is found in all living cells, naturally decreases with age.

A 2016 article by Evandro Fei Fang and colleagues in the journal Cell Metabolism reports that giving mice and roundworms supplemental NAD+ postponed cell aging and extended the lives of these animals.

The researchers hope this research might eventually help patients with Alzheimer’s and Parkinson’s’ diseases.