New Drug Cariprazine May Be Effective in Acute Mania
Medscape Medical News reported that a new antipsychotic, cariprazine, may be effective in treating acute mania in bipolar I disorder. The drug is produced by Forest Laboratories Inc. and Gedeon Richter Plc.
The data showed that patients with acute manic episodes who were treated with cariprazine experienced significant improvements in symptoms compared with patients given placebo, as measured by the Young Mania Rating Scale (YMRS). These improvements, report the companies, were observed as early as day 5 of treatment and at each subsequent time point in the study.
The multicenter, double-blind placebo-controlled parallel group study showed statistically significant improvement in patients receiving cariprazine in each of 2 dosages — 3 to 6 mg/day (-6.1 points, P < 0.001) and 6 to 12 mg/day (-5.9 points, P < 0.001) — as compared with patients receiving placebo.
See here for a history of the research on cariprazine.
