Dextromethorphan potentiates the anti-depressant effects of SSRIs
Maji et al reported in Psychiatry Research (2024) that dextromethorphan 30mg compared to placebo potentiated the antidepressant effects of SSRIs on all measures and had few side effects. It is FDA-approved to potentiate bupropion.
Now it looks like a more general property.
New Medication for PTSD Approved
February 3, 2025 · Posted in A - Very Important and Reading for Consideration, Current Treatments, Potential Treatments · Comment
The double-blind, phase 3 trial included 416 adults aged 18-65 years with a DSM-5 diagnosis of PTSD and symptoms for at least 6 months prior to screening.
Patients underwent a 1-week placebo-run in period followed by randomization to daily oral brexpiprazole 2-3 mg plus sertraline 150 mg or daily sertraline 150 mg plus placebo for 11 weeks.
