Preventing Cognitive Decline in Bipolar Disorder

August 14, 2013 · Posted in Current Treatments 

confused man

Here are some suggestions from BNN Editor-in-Chief Robert M. Post, MD for preventing cognitive decline in patients with bipolar disorder.

1. Prevent Episodes with Long-term Prophylaxis

2. Remove Sedating or Impairing Drugs

3. Add Folate to Decrease Homocysteine

4. Treat Depression to Remission

5. Consider Adding:

         a. Bupropion (Wellbutrin) for Mood and ADHD

         b. Modafinil (Provigil) for Attention and ADHD

         c. A Stimulant for ADHD

6. Add Lithium at 150mg/day for Neuroprotection in Mild Cognitive Impairment

7. Add Levitiracetam at 125mg/day to Decrease Hippocampal Hyperactivity

8. Treat Dementia Symptoms Early with:

         a. Memantine (Namenda) AND/OR

         b. Acetylcholine Esterase Inhibitors Such As Donepezil (Aricept)

9. Consider Adding an Anti-inflammatory Agent


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