Family History of Alcohol Dependence Predicts Antidepressant Response to an NMDA Antagonist

LE Phelps reported in Biol. Psy (2009) that subjects with a family history of alcohol dependence showed significantly greater improvement in MADRS scores compared with subjects who had no family history of alcohol dependence.

They concluded that a family history of alcohol dependence appears to predict a rapid initial antidepressant response to the NMDA receptor antagonist ketamine.

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