Vortioxetine Improves Cognition, Major Depression in Early Dementia
June 23, 2023 · Posted in B - Clinically Important for Future Consideration, Potential Treatments · Comment
Vortioxetine (5mg then 10mg) significantly improves depressive symptoms, cognitive performance, functioning, and quality of life at 12 weeks in patients with both major depressive disorder (MDD) and early-stage dementia. In addition to blocking 5HT (serotonin) reuptake vortioxetine antagonizes 5 serotonin receptors with 5HT3 and 5HT7 likely accounting for the positive effects on processing speed and cognitive functioning.
