Keep Your Heart and Cardiovascular System Healthy
Middle aged folks, watch your risk factors for cardiovascular disease. These include: high blood pressure, cholesterol, weight, and blood sugar (diabetes).
According to Heartwire, an article in the New England Journal of Medicine indicates that having any of these risk factors increases the likelihood of cardiovascular disease later in life. The more risk factors one has, the greater the increase in risk.
Across the whole meta-analysis, participants with no risk factors at age 55 (total cholesterol level: <180 mg/dL;
blood pressure: <120 mm Hg systolic and 80 mm Hg diastolic; nonsmoking; nondiabetic) had drastically better odds
of avoiding death from cardiovascular disease through the age of 80 than participants with two or more major risk
factors (4.7% vs 29.6% among men and 6.4% vs 20.5% among women).People with an optimal risk-factor profile also had lower lifetime risks of fatal coronary heart disease or nonfatal MI (Editor’s Note: myocardial infarction, or heart attack) (3.6% vs 37.5% among men, <1% vs 18.3% among women) and fatal or nonfatal stroke (2.3% vs 8.3% among men,
5.3% vs 10.7% among women), compared with those with two or more risk factors.
What this article does not mention is that depression is a risk factor for coronary artery disease, and should be treated just as aggressively and persistently as the other cardiovascular risk factors.
Also as we’ve written before in the BNN, exercise is one element of a healthy life style that can positively affect all of these risk factors. Starting a healthy diet and exercise regimen in middle age will have long-term positive effects and reduce risks later in life.
BDNF Related to Cognition and Fitness in Men with Coronary Artery Disease
At the 51st Annual Meeting of the National Institute of Mental Health’s New Clinical Drug Evaluation Unit (NCDEU) in 2011, Walter Swardfager and colleagues from Toronto, Ontario presented a study indicating that brain-derived neurotrophic factor (BDNF) concentrations in blood are associated with cognitive performance and cardiopulmonary fitness in people with coronary artery disease.
In 88 mostly male subjects with a mean age of 63 years, cardiopulmonary fitness was directly correlated with BDNF in blood as well as higher scores of cognition on two tests, the mini mental status exam and the digit symbol coding task. The investigators concluded that better fitness, psychomotor processing speed, and overall cognition were consistent with a hypothesis that BDNF protects midbrain dopaminergic neurons against inflammatory neurodegenerative processes.
Blood levels of interleukin 6, a measure of inflammatory cytokines, were associated with lower mini mental status scores in a multivariate analysis that controlled for BDNF levels.
Editor’s note: BDNF appears to be necessary for long-term learning and memory. Meta-analyses indicate that BDNF levels are low in depression and improve with euthymia. Many mood stabilizers including lithium, valproate, carbamazepine, and lamotrigine and most types of antidepressants are able to increase BDNF. The current findings linking BDNF with better cardiopulmonary fitness and cognition continue to emphasize the potential importance of BDNF beyond its role as a marker for depression.
In BNN Volume 12, Issue 3 from 2008, we reported on the data of Schmidt and Duman, which indicated that BDNF administered in a subcutaneous minipump is able to reverse many depressive-like behaviors in an animal model of depression, suggesting that even peripheral BDNF may have a role in the central nervous system.
